方法与技术：上 LarryR.Squire[著] 9787030280855 科学出版社

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作者: LarryR.Squire [著]
出版社: 科学出版社
ISBN: 9787030280855

出版时间: 2009-04
装帧: 平装
开本: 16开

作者: LarryR.Squire [著]
出版社: 科学出版社

ISBN: 9787030280855
出版时间: 2009-04

装帧: 平装
开本: 16开

售价 91.10 6.6折

定价￥138.00

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上书时间2024-04-16

数量: 库存30件

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商品分类：

医药卫生

货号：

6638988

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目录
动物模型与方法
Aging and Memory in Animals
Aging: Invertebrate Models of Normal Brain Aging
Alzheimers Disease: Transgenic Mouse Models
Animal Models of Alzheimers Disease
Animal Models of Amnesia
Animal Models of Huntingtons Disease
Animal Models of Inherited Retinal Degenerations
Animal Models of Motor and Sensory Neuron Disease
Animal Models of Parkinsons Disease
Animal Models of Stroke
BAC Transgenesis: Cell-Type Specific Expression in the Nervous System.
Drosophila Apterous Neurons: From Stem Cell to Unique Neuron
Drug Addiction: Behavioral Pharmacology of Drug Addiction in Rats
Episodic Memory: Assessment in Animals
Executive Function and Higher-Order Cognition: Assessment in Animals
Inherited Macular Degenerations: Animal Models
Invertebrate Models to Study Learning and Memory: Lymnaea
Learning and Memory m Invertebrate Models: Tritonia
Learning and Memory m Invertebrat...

内容摘要
Mice pose advantages over other species，such as rats，dogs，pigs，or primates，in several aspects：（1）It ISrelatively easy to house large numbers of them；（2）the mouse genome is better characterized than that of anyother mammaI except humans；（3）many geneticallyaltered transgenic knockout and knockin lines andgenetically characterized mouse strains are availablefor crossbreeding and further genetic analysis；（4）cognitive studies can be done in appropriate strains of mice，such as C5786／SJL and 129S6，making the mespely relevant to the study of AD；and（5）studies in invertebrates，while useful，willlack some relevance in pharmacological studies and pathogenic in vestige.Tions To create transgenic mice with salient features of AD.investigators must take care in several aspects of design and development.The most important factors are the selection of the gene or gene variant to be expressed，the promoter driving transgene expression,the background strain of the mice. and the levels and distribution of transgenic protein expression achieved in the brain.The mouse lines with the most robust neuropathological phenotypes have been developed using the method of pronuclear microinjection oftransgenes into fertilized ocytes（Figure 1）.B0th wildtype and variant human APP and tau genes have been used to generate mice that develop neuropathology related to AD.Transgenes containing mutations linked to aut osomaI dominant AD or FDTP generate morerobust neuropathology than transgenes encoding wild-type genes.Although mutations in presenilin一1 and presenilin.2 genes lead to early-onset ADin humans，mice expressing presenilin gene variants do not develop neuropathology per 5e.In the presence of human APP transgenes，howeve the presenilin gene variants accelerate plaque deposition in trans genic mice. ……

精彩内容
《神经科学百科全书5:方法与技术(上导读版)》原书篇幅巨大，为所有神经科学百科全书之首。由来自世界各地的2400多位专家撰稿人合力打造，覆盖了神经科学全部主要领域。书中每个词条在收入书中之前均经过顾问委员会的同行评议，词条中均含有词汇表、引言、参考文献和丰富的交叉参考内容。主编为有名神经科学家、美国神经科学学会前主席LarryR Squire内容平易.本科生即可读懂。深度和广度专享.足可满足专家学者的需要。导读版精选原书中的部分主题，按内容重新编排，更适合国内读者购买和阅读。
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方法与技术：上 LarryR.Squire[著] 9787030280855 科学出版社

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