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阿利森 著 / 高等教育出版社 / 2008-06 / 平装
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国外优秀生命科学教学用书:基础分子生物学(影印版)
Thebeginningsofmolecularbiology,ThestructureofDNA,Genomeorganization:fromnucleotidestochromatin,TheversatilityofRNA,Fromgenetoprotein,DNAreplicationandtelomeremaintenance,DNArepairandrecombination,RecombinantDNAtechnologyandmolecularcloning。
1Thebeginningsofmolecularbiology1.1Introduction1.2HistoricalperspectiveInsightsintoheredityfromroundandwrinkledpeas:MendeliangeneticsInsightsintothenatureofhereditarymateriaL:thetransformingprincipleisDNACreativityinapproachleadstotheonegene-oneenzymehypothesisTheimportanceoftechnologicaladvances:theHershey-ChaseexperimentAmodelforthestructureofDNA:theDNAdoublehelixChaptersummaryAnalyticalquestionsSuggestionsforfurtherreading2ThestructureofDNA2.1Introduction2.2Primarystructure:thecomponentsofnucleicacidsFive-carbonsugarsNitrogenousbasesThephosphatefunctionalgroupNucleosidesandnucteotides2.3Significanceof5and32.4Nomenclatureofnucleotides2.5ThelengthofRNAandDNA2.6SecondarystructureofDNAHydrogenbondsformbetweenthebasesBasestackingprovideschemicalstabilitytotheDNAdoublehelixStructureoftheWatson-CrickDNAdoublehelixDistinguishingbetweenfeaturesofalternativedouble-helicalstructuresDNAcanundergoreversiblestrandseparation2.7UnusualDNAsecondarystructuresSlippedstructuresCruciformstructuresTriplehelixDNADiseasebox2.1FriedreichsataxiaandtriplehelixDNA2.8TertiarystructureofDNASupercoilingofDNATopoisomerasesrelaxsupercoiledDNAWhatisthesignificanceofsupercoitinginvivo?Diseasebox2.2Topoisomerase-targetedanticancerdrugsChaptersummaryAnalyticalquestionsSuggestionsforfurtherreading3Genomeorganization:fromnucleotidestochromatin3.1Introduction3.2EukaryoticgenomeChromatinstructure:historicalperspectiveHistonesNucleosomesBeads-on-a-string:the10nmfiberThe30nmfiberLoopdomainsMetaphasechromosomesAlternativechromatinstructures3.3Bacterialgenome3.4Plasmids3.5BacteriophagesandmammalianDNAvirusesBacteriophaqesMammalianDNAViruses3.6Organellegenomes:chloroplastsandmitochondriaChloroplastDNA(cpDNA)MitochondrialDNA(mtDNA)Diseasebox3.1MitochondrialDNAanddisease3.7RNA-basedgenomesEukaryoticRNAvirusesRetrovirusesViroidsOtherSubviralpathoqensDiseasebox3.2AvianfluChaptersummaryAnalyticalquestionsSuggestionsforfurtherreading4TheversatilityofRNA4.1Introduction4.2SecondarystructureofRNASecondarystructuremotifsinRNABase-pairedRNAadoptsanA-typedoublehelixRNAhelicesoftencontainnoncanonicalbasepairs4.3TertiarystructureofRNAtRNAstructure:importantinsiqhtsintoRNAstructuralmotifsCommontertiarystructuremotifsinRNA4.4KineticsofRNAfolding4.5RNAisinvolvedinawiderangeofcellularprocesses4.6Historicalperspective:thediscoveryofRNAcatalysisTetrahymenaqroUPIintronribozymeRNasePribozymeFocusbox4.1:TheRNAWorld4.7RibozymescatalyzeavarietyofchemicalreactionsModeofribozymeactionLargeribozymesSmallribozymesChaptersummaryAnalyticalquestionsSuggestionsforfurtherreading5Fromgenetoprotein5.1Introduction5.2Thecentraldogma5.3ThegeneticcodeTranslatingthegeneticcodeThe21stand22ndgeneticallyencodedaminoacidsRoleofmodifiednucleotidesindecodingImplicationsofcodonbiasformolecularbiologists5.4ProteinstructurePrimarystructureSecondarystructureTertiarystructureQuaternarystructureSizeandcomplexityofproteinsProteinscontainmultiplefunctionaldomainsPredictionofproteinstructure5.5ProteinfunctionEnzymesarebiologicalcatalystsRegulationofproteinactivitybypost-translationalmodificationsAllostericregulationofproteinactivityCyclin-dependentkinaseactivationMacromolecularassemblages5.6ProteinfoldingandmisfoldingMoLecularchaperonesUbiquitin-mediatedproteindegradationProteinmisfoldingdiseasesDiseasebox5.1PrionsChaptersummaryAnalyticalquestionsSuggestionsforfurtherreading6DNAreplicationandtelomeremaintenance6.1Introduction6.2HistoricalperspectiveInsightintothemodeofDNAreplication:theMeselson-StahlexperimentInsightintothemodeofDNAreplication:visualizationofreplicatingbacterialDNA6.3DNAsynthesisoccursfrom5→36.4DNApolymerasesaretheenzymesthatcatalyzeDNAsynthesisFocusbox6.1BacterialDNApolymerases6.5SemidiscontinuousDNAreplicationLeadingstrandsynthesisiscontinuousLaggingstrandsynthesisisdiscontinuous6.6NuclearDNAreplicationineukaryoticcellsReplicationfactoriesHistoneremovalattheoriginsofreplicationPrereplicationcomplexformationattheoriginsofreplicationReplicationLicensing:DNAonlyreplicatesoncepercellcycleDuplexunwindingatreplicationforksRNAprimingofLeadingstrandandLaggingstrandDNAsynthesisPolymeraseswitchingElongationofLeadingstrandsandLaggingstrandsProofreadingMaturationofnascentDNAstrandsTerminationHistonedepositionFocusbox6.2ThenamingofgenesinvolvedinDNAreplicationDiseasebox6.1SystemiclupuserythematosusandPCNA6.7ReplicationoforganelleDNAModelsformtDNAreplicationReplicationofcpDNADiseasebox6.2RNaseMRPandcartilage-hairhypoplasia6.8Rollingcirclereplication6.9Tetomeremaintenance:theroleoftetomeraseinDNAreplication,aging,andcancerTelomeresSolutiontotheendreplicationproblemMaintenanceoftelomeresbytelomeraseOthermodesoftelomeremaintenanceRegulationoftelomeraseactivityTelomerase,aging,andcancerDiseasebox6.3Dyskeratosiscongenita:lossoftelomerasefunctionChaptersummaryAnalyticalquestionsSuggestionsforfurtherreading7DNArepairandrecombination7.1Introduction7.2TypesofmutationsandtheirphenotypicconsequencesTransitionsandtransversionscanleadtosilent,missense,ornonsensemutationsInsertionsordeletionscancauseframeshiftmutationsExpansionoftrinucleotiderepeatsleadstogeneticinstability7.3GeneralclassesofDNAdamageSinglebasechangesStructuraldistortionDNAbackbonedamageCellularresponsetoDNAdamage7.4Lesionbypass7.5DirectreversalofDNAdamage7.6RepairofsinglebasechangesandstructuraldistortionsbyremovalofDNAdamageBaseexcisionrepairMismatchrepairNucleotideexcisionrepairDiseasebox7.1Hereditarynonpolyposiscolorectalcancer:adefectinmismatchrepair7.7Double-strandbreakrepairbyremovalofDNAdamageHomologousrecombinationNonhomologousend-joiningDiseasebox7.2Xerodermapigmentosumandrelateddisorders:defectsinnucleotideexcisionrepairDiseasebox7.3Hereditarybreastcancersyndromes:mutationsinBRCA1andBRCA28RecombinantDNAtechnologyandmolecularcloning9Toolsforanalyzinggeneexpression10Transcriptioninprokaryotes11Transcriptionineukaryotes12Epigeneticandmonoallelicgeneexpression13RNAprocessingandpost-transcriptionalgeneregulation14Themechanismoftranslation15Geneticallymodifiedorganisms:useinbasicandappliedresearch16Genomeanalysis:DNAtyping,genomicsandbeyond17MedicalmolecularbiologyGlossaryIndex
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开播时间:09月02日 10:30