Despite their demonstrated effectiveness, the long term use of microscale neuroprosthetic devices is compromised by the post-implantation tissue reaction that often forms around the device. This book studies ways to improve the tissue reaction to implant ted neuroprosthesis by use of a controlled drug release mechanism, quantified by novel measurement techniques. The author describes solutions to the problem of tissue reaction around microscale neuroprostheses and an also examines an improvement in neura