The term psychoneuroimmunology was originally coined to acknowledge the existence of functional interactions between the brain, the immune system and the endocrine system. As our understanding deepens of the interplay between the brain and the way bodies function, the field continues to grow in importance. This comprehensive handbook is an authoritative source of information on the history, methodology and development of research into psychoneuroimmunology. The interdisciplinary nature of the contributions reflects the fact that the subject is a multifaceted field of research integrating the traditionally separate subjects of biological and behavioral science. Psychoneuroimmunology attains a realistic appreciation of the interplay between different biological systems as they collectively maintain health and combat environmental challenges to health. Background material is balanced by a detailed assessment of emerging topics in psychoneuroimmunological research that focuses on the clinical and practical implications of findings from empirical studies on both humans and animals. While specialist readers will appreciate the coverage of progress made in psychoneuroimmunology, newcomers will gain much from its informed and accessible introduction to the field, as well as its exploration of a variety of methodological approaches.