本书原定价1750.00美元，净重12080克，馆藏。【图书分类：医药、卫生之药学之毒物学（毒理学）】Encompassing 150 articles written by leading scientists in thefield, the third edition of General and Applied Toxicologyprovides a comprehensive and in-depth review of the basic scienceof toxicology, its specializations, and the application oftoxicological knowledge. This new edition reflects developments within the field thathave taken place since the second edition was published in1999. These include:
New information developed in the areas of both the fundamentaland applied aspects of toxicology Considerable increase in the development of fundamentalinformation and its applications, refinement of technical methods,advances in mechanistic toxicology, and greater interest in areasof toxicology previously regarded as of limited scope Changing approaches to methodological, interpretative,regulatory, and ethical aspects of basic and appliedtoxicology General and Applied Toxicology, 3rd Edition isthe first port of call for academic researchers, industrialresearchers, regulatory professionals, and advanced studentslooking for timely and authoritative information in the field. Dueto the increase in public and media interest in exposure to toxicsubstances, this provides an indispensable general reference sourcefor general physicians, lawyers, law enforcement agencies,information resource facilities, and members of the generalpublic.
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Contents： Preface to Third Edition. Preface to Second Edition. Preface to First Edition. List of Contributors. Frequently used Abbreviations. VOLUME 1. PART ONE: BASIC SCIENCE. 1 Basic Elements of Toxicology (Bryan Ballantyne, Timothy C. Marrs and Tore Syversen). 2 Acute Toxicity (David J. Andrew). 3 Repeated Exposure Toxicity (Bryan Ballantyne). 4 Biotransformation of Xenobiotics (John A. Timbrell and Timothy C. Marrs). 5 Toxicokinetics of Xenobiotic and Metabolite Distribution and Excretion (Mario A. Inchiosa, Jr. and Mario E. Inchiosa). 6 Toxicokinetics (Ashley Roberts and Andrew G. Renwick). 7 Physiologically Based Pharmacokinetic Modelling (Hon-Wing Leung). 8 Toxicology of Chemical Mixtures (Kannan Krishnan and Jonathan Boyd). 9 Evaluation of Toxicological Interactions for the Dose-Response Assessment of Chemical Mixtures (Kannan Krishnan, Sastry Isukapalli and Jonathan Boyd). PART TWO: MOLECULAR AND CELLULAR ASPECTS OF TOXICOLOGY. 10 Molecular and Cellular Concepts in Toxicology (Michael A. Lynes). 11 Cell Death and Apoptosis (Sidhartha D. Ray and George B. Corcoran). 12 Introduction to Mitochondrial Toxicity (Yvonne Will and James A. Dykens). 13 Toxicity of Peroxisome Proliferators (John P. Vanden Heuvel). 14 Cellular Tight Junctions as Mediators of Adverse Effects (Yula Sambuy). 15 Reactive Oxygen Species in the Induction of Toxicity (Giorgio Lenaz and Paola Strocchi). 16 Glutathione and Glutathione-S-Transferase in Detoxification Mechanisms (Xianchun Li). 17 Nitric Oxide Pathways in Toxic Responses (Jeffrey D. Laskin, Diane E. Heck and Debra L. Laskin). 18 A Metabolomic Perspective of Small Molecule Toxicity (Andrew D. Patterson and Jeffrey R. Idle). 19 Xenobiotic-Induced Inflammation: Pathogenesis and Mediators (Peter J. M. Clements). 20 Chemokines as Mediators of Toxicant-Induced Inflammation and Fibrosis (Francois Huaux, Sandra Lo Re and Dominique Lison). 21 Toxicogenomics and the Evolution of Systems Toxicology (Michael D. Waters and B. Alex Merrick). 22 Endocrine Disruption in Toxic Responses (Shigeyuki Kitamura, Kazumi Sugihara, Kazuo Nakamura, Yaichiro Kotake, Akihiko Kashiwagi and Nariaki Fujimoto). VOLUME 2. PART THREE: FACTORS INFLUENCING TOXICOLOGY. 23 Environmental and Endogenous Factors Determining the Expression of Toxicity (Karen E. Stine). 24 Chronotoxicology (Karam F. Soliman and Elizabeth A. Mazzio). 25 Effects of Chirality on Toxicity (Mae Grace Nilos, Jay Gan and Daniel Schlenk). 26 The Influence of Temperature on Toxicity (Christopher J. Gordon and Pamela J. Rowsey). 27 Development of Tolerance to the Toxicity of Xenobiotics (Frode Fonnum). PART FOUR: METHODOLOGY. 28 Statistics for Toxicology (Peter N. Lee and David Lovell). 29 Pathological Techniques in Toxicology (Peter Greaves). 30 Clinical Chemistry in Toxicity Testing: Scope and Methods (Sylvie Gosselin, Lila Ramaiah and Lesley Earl). 31 Haematology and Toxicology (Timothy C. Marrs and Simon Warren). 32 Imaging Techniques in Neurotoxicology Research and Development (Philippe Hantson and Thierry Duprez). 33 Alternatives to In vivo Studies in Toxicology (Shayne C. Gad). 34 Antidotal Studies (D. Nicholas Bateman and Timothy C. Marrs). 35 Toxicity Data Obtained From Human Studies (Martin F. Wilks and Hugo Kupferschmidt). 36 Significance of Biochemical Markers in Applied Toxicology (Fernando Gil and Antonio F. Hernández). 37 Oncology Biomarkers (Michael A. Tainsky). 38 Quality Assurance in Toxicology Studies (J. Rodney Pateman). 39 Animal Welfare in the Toxicology Laboratory (Roy C. Myers and Bennett J. Varsho). 40 Chemical and Biological Occupational Hazards in the Toxicology Laboratory (Bryan Ballantyne). 41 Information Resources for Toxicology (Philip Thomas Copestake). PART FIVE: TOXICITY BY ROUTES. 42 Toxicities Associated with Parenteral Nutrition (Judy L. Aschner and Heather M. Furlong). 43 Peroral Toxicity (William J. Brock). 44 Cutaneous Toxicology (Jim E. Riviere and Nancy A. Monteiro-Riviere). 45 Inhalation Toxicity (Geoff H. Pigott). 46 Mixed Routes of Exposure (John J. Clary). ……
Review： "This is an easy-to-read, well referenced book that will serve asan excellent companion to traditional core pharmaceutics texts."(The Annals of Pharmacotherapy, September 2010)
“Overall this is an excellent, comprehensive reference ontoxicology and a good backup for a textbook, with abundant,excellent illustrations.” (CHOICE, September 2010)
"The main merit of this book is as an immense educationalresource, primarily for students, covering toxicology in itsbroadest applications and containing highly specialised materialnot covered elsewhere. Many chapters are first class reviewswritten by leading authorities and these will provide advancedsubject reviews from which to launch into the primary literature.It has clearly been a massive undertaking which has been completedwith commendable commitment and production quality is excellent. Itis also a text of few competitors and outstandingly good value, andall things considered must be rated as excellent for quality,novelty, scope and overall contribution to the toxicologicalliterature." (BTS Newsletter, Summer 2010)
"There are many wonderfully and masterfully written chaptersthat relate basic science to its practical applications." (TheAnnals of Pharmacotherapy - September 2010).
About the Author： Bryan Ballantyne, MD, DSc, PhD, FFOM, FACOM, FAACT, FATS,FRCPath, FIBiol (deceased) was an IndependentConsultant inOccupational and Clinical Toxicology. Prior to that he held thepositions of: Director of Applied Toxicology for Union CarbideCorporation in Connecticut, USA; Senior Medical Officer and Head ofthe Section of Toxicology and Pathology at the UK Chemical DefenseEstablishment; Adjunct Professor of Toxicology at the University ofPittsburgh; and Adjunct Professor of Pharmacology and Toxicology atWest Virginia University. He was a Fellow of the Faculty ofOccupational Medicine, Royal College of Pathologists, Academy ofToxicological Sciences, and the Institute of Biology. He wasformerly a member of the Scientific Subcommittee on Pesticides ofthe Ministry of Agriculture, Fisheries and Food, UK and of theCommittee of Experts on Pesticides, Council of Europe. He has beena member of the Council on Scientific Affairs of the AmericanCollege of Occupational and Environmental Medicine, and of theBoard of Trustees of the American Academy of Clinical Toxicology.Dr. Ballantyne was also the editor or co-editor of seven books ontoxicology and related areas and a member of the Editorial Board offi ve toxicology journals, including Toxicology Methods,Forensic Science International, and the Journal of AppliedToxicology.
Timothy Marrs, MD, DSc, MRCP, FRCPath, FIBiol is aconsulting toxicologist for Edentox. He was formerly chieftoxicologist at the Food Standards Agency in London, and beforethat Senior Medical Offi cer at the Department of Health. Previousto that, he was Senior Medical Offi cer (Research) at the ChemicalDefence Establishment, Porton Down. He is also consulting clinicaltoxicologist at the West Midlands Poisons Unit in Birmingham. He isa Fellow of the Royal College of Pathologists, Royal College ofPhysicians of London and of the Academy of Toxicological Sciences.He has also been the editor of a number of books including,Organophosphates and Health and most recently ChemicalWarfare Agents Toxicology and Treatment. He has written anumber of papers on toxicology and allied subjects. He is a memberof a number of government committees.
Tore Syversen, MSc, DrPhil is Professor of Pharmacologyand Toxicology at the Norwegian University of Science andTechnology Trondheim, Norway. He has been professor of toxicologyat NTNU since 1977 and has been engaged in the teaching oftoxicology to students of medicine, natural sciences andtechnology. His main research interest has been metals in health,nutrition as well as in occupational medicine and environmentalsciences. Current interests also include using cell cultures formechanism studies as well as the health challenges introduced bynanoparticles.
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